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Mi Kyeong Lee

Mi Kyeong Lee

Chungbuk National University, South Korea

Title: Polyamines and fl avonoids of bee pollen with anti-tyrosinase and antioxidant activity


Biography: Mi Kyeong Lee


Bee pollen is flower pollen collected by bees with nectar and salivary substances and rich in nutrients. It has been used as traditional medicine and supplementary nutrients with diverse activities. Recently, antioxidant and tyrosinase inhibitory activity of bee pollen extract have been reported. For the characterization of constituents of compounds from bee pollen, isolation of compounds from the bee pollen of Quercus mongolica were conducted using a various column chromatography and their structures were determined by 1D-NMR (1H NMR and 13C NMR), 2D-NMR (HSQC, HMBC, NOESY) and HRESI-TOF-MS. Investigation resulted in the isolation of 38 compounds including 18 polyamines and 19 flavonoids. Polyamines were further divided into two putrescines, fifteen spermidines and one spermine. Flavonoids were further grouped as one flavanone, 15 flavones and one isoflavonoid. Among them, seven polyamines were first reported from nature; One putrescine, N1-(E)-N6-(Z)-di-p-coumaroyl-putrescine named mogolicine A, five spermidines, N1-acetyl-N5,N10-(E)-di-p-4-methoxycinnamoyl-spemidine, N1-acetyl-N5-(Z), N10-(E)-di-p-4-methoxycinnamoyl-spermidine, N1-acetyl-N5,N10-(Z)-di-p-4-methoxycinnamoyl-spermidine, N1-(E),N5-(Z),N10-(E)-tri-p-4-methoxycinnamoyl-spermidine and N1-p-anisamide-N5-(Z),N10-(E)-di-p-4-methoxycinnamoyl-spermidine, named mogolidines  A-F, and one spermine, N1,N5,N10,N14-(E)-tetra-p-coumaroylspermine named mogolidine A.   The isolated compounds showed antioxidant and anti-tyrosinase activity. Interestingly, polyamines showed more strong inhibition on tyrosnase with IC50 values of 19.5-31.7 µM whereas flavonoids showed potent antioxidant activity with IC50 values of 9.7-34.3 µM. These results provide useful information about bee pollen as antioxidant ingredients and cosmetic therapeutics to reduce oxidative stress and hyperpigmentation.